Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
نویسندگان
چکیده
BACKGROUND Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels. METHODS Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA. RESULTS Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group. CONCLUSION Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.
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